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A powerful virus escapes from a British research facility. Transmitted in a drop of blood and devastating within seconds, the virus locks those infected into a permanent state of murderous rage. Within 28 days the country is overwhelmed and a handful of survivors begin their attempts to salvage a future, little realising that the deadly virus is not the only thing that threatens them.

Samantha Caine, suburban homemaker, is the ideal mom to her 8 year old daughter Caitlin. She lives in Honesdale, PA, has a job teaching school and makes the best Rice Krispie treats in town. But when she receives a bump on her head, she begins to remember small parts of her previous life as a lethal, top-secret agent. Her old chums in the Chapter are now out to kill her so she enlists the help of a cheap detective named Mitch. As Samantha remembers more and more of her previous life, she becomes deadlier and more resourceful. Both Mitch and Charly proceed to do the killing thing, the bleeding thing and the shooting thing.

After receiving license to kill from the MI-6, the secret agent James Bond follows his leads and avoids the destruction of the greatest airplane in the world in Miami plotted by the evil banker Le Chiffre to crash the bonds in the stock market and break the air flight company. The banker loses the funds of international terrorist organizations and organizes a poker game in Casino Royale, in Montenegro, to raise the money of the investors. James Bond travels with the British accountant Vesper Lynd to bet and defeat La Chiffre and force him to look for protection with the MI-6, disclosing the names of the terrorists. James wins, but is double-crossed, in a game of betrayals and murders.

The British discover that someone has perfected a way of tracking submerged submarines and is offering the technology to the highest bidder. An international crisis breaks when a Royal Navy Polaris submarine equipped with sixteen nuclear warheads disappears while on patrol. The British send agent James Bond to secure the tracking device and locate the missing vessel before its missiles are launched at the West.